George was born in Dorchester, Suffolk, Massachusetts on March 20, 1688/89, the son of Amiell Weekes and Abigail Trescott (Rogers). George died in 1770 at Harwich, Barnstable, Massachusetts at the age of 81. In the later years of his life, his mind was clouded, which led to aimless wanderings about the country. He died from exposure to the cold in the low ground south of Harwich Academy, known from the circumstance as "Weekes' Hollow" to the present day -- being more than 80 years old.

A short distance beyond the new cemetery in Harwich, in an open field where there are a few ancient graves, is one with this inscription: "George Weekes, born in Dorchester, Mass., A.D. 1683, came to Harwich, married Deborah Wing Oct. 15, 1714, preached to the Indians, and perished in a snow storm in the hollow one hundred rods south of this spot. he was a grandson of George Weekes, a Huegenot, who fled to England, and came to America in 1630."

George Weekes had lived in Boston, but in 1714 removed to Harwich. He was dismissed from the Old South Church in Boston March 27, 1720, and joined the church at Harwich (north side) under the care of Rev. Nathaniel Stone. He afterwards removed to the south part of the town, where many of his descendants now live, and where he carried on a farm. George Weekes was not "liberally" educated, but was well versed in the theological books of the day, and was familiar with the scriptures. In 1730, though not ordained by human hands, he commenced preaching to the Indians, who were located toward the south and far removed from the meeting house, which was on the north side of the parish of 23 square miles. Mr. Weekes built a house of worship for the Indians at his own expense. Notwithstanding these facts, the pastor, Mr. Stone, objected, but does not appear to have insisted on a discontinuance. Learning, however, the Mr. Weekes on one or more occasions preached to some of his white neighbors, who, no doubt, were glad to assemble occasionally on a week day or stormy Sunday for religious instruction and conference, being as they were so far removed from their regular place of worship. Mr. Stone vigorously protested and complained to the church in regard to the matter. His grounds of complaint were that Mr. Weekes had "no more if so much as an early common education," that he "had thrust himself into the meeting," that he "had preached to a people of whom I have the pastoral charge, without my leave and against my declared mind." There does not appear to have been any charge of want of orthodoxy. Some years later, Mr. Weekes seems to have taken pity upon an unfortunate woman and taken her with her child into his house. Some took offense at this and would not come to the Lord's table with him, in view of which state of feeling he absented himself from the communion. On being called to account for his absence, he made explanations which were accepted by the church as in a measure satisfactory, but at the same time he was advised to dismiss the woman from his house and to avoid "her conversations as much as convenient." There seems to have been no charge against him of impropriety.

Deborah Wing and George Weekes had the following children:

1. Abigail Weekes was born August 29, 1715 in Harwich, Barnstable, Massachusetts to Deborah Wing and George Weekes. There is also a record that states that Abigail Weeks was admitted to full comunion on February 22, 1740/41 of the First Parish of Harwich.

2. Mehitable Weekes was born April 21, 1717

3. Deborah Weekes was born July 26, 1718

4. Ammiel Weekes was born April 10, 1720

5. Hannah Weekes was born September 20, 1721

6. Elizabeth Weekes was born September 16, 1724 at Harwich, Barnstable, Massachusetts. Elizabeth was baptized on September 20, 1724 at the First Parish of Harwich. There is no record of any marriage or even of her death. There is a letter that her sister wrote (who was now known as Mrs. Penny) in 1761...Mrs. Penny writes that "sister Edey" is declining in health and wishes her brother Ammiel to visit her.

7. Baby Boy Weekes, was born on January 24, 1725/26 at Harwich, Barnstable, Massachusetts. Baby Boy Weekes died about 20 hours after his birth.